Article
Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro†
17 Feb 2017
Abstract excerpt
Existing methods for evaluating the potential gonadotoxicity of environmental agents and pharmaceutical compounds rely heavily on animal studies. The current gold standard in vivo functional assays in animals are limited in their human predictive capacity. In addition, existing human two-dimensional in vitro models of testicular toxicity do not accurately reflect the in vivo situation. A more reliable testicular...
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