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Article

CD44 Facilitates Epithelial-to-Mesenchymal Transition Phenotypic Change at Acquisition of Resistance to EGFR Kinase Inhibitors in Lung Cancer.

Molecular cancer therapeutics - 1 Oct 2018

Suda Kenichi, Murakami Isao, Yu Hui, Kim Jihye, Tan Aik-Choon, Mizuuchi Hiroshi, Rozeboom Leslie, Ellison Kim, Rivard Christopher J, Mitsudomi Tetsuya, Hirsch Fred R

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) is one of the acquired resistance mechanisms to EGFR tyrosine kinase inhibitors (TKI) in lung cancers. Because EMT is related to tumor invasion, metastases, and resistance to various treatments, it is important to prevent the emergence of EMT. However, molecular mechanism(s) underlying EMT phenotypic changes, as well as biomarker(s) that predict the emergence of EMT in...

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Identifiers

PMID: 30049789
DOI: 10.1158/1535-7163.MCT-17-1279

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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