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Article

Effect of dasatinib on EMT-mediated-mechanism of resistance against EGFR inhibitors in lung cancer cells.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2017

Sesumi Yuichi, Suda Kenichi, Mizuuchi Hiroshi, Kobayashi Yoshihisa, Sato Katsuaki, Chiba Masato, Shimoji Masaki, Tomizawa Kenji, Takemoto Toshiki, Mitsudomi Tetsuya

Abstract excerpt

OBJECTIVE: The epithelial to mesenchymal transition (EMT) is associated with acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in certain non-small cell lung cancers that harbor EGFR mutations. Because no currently available drugs specifically kill cancer cells via EMT, novel treatment strategies that overcome or prevent EMT are needed. A recent report suggested that...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Drug Therapy, Combination

Share to Epithelial-Mesenchymal Transition

Share to ErbB Receptors

Share to Erlotinib Hydrochloride

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Source

Identifiers

PMID: 28213007
DOI: 10.1016/j.lungcan.2016.12.012

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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