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Article

Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2011

Suda Kenichi, Tomizawa Kenji, Fujii Makiko, Murakami Hideki, Osada Hirotaka, Maehara Yoshihiko, Yatabe Yasushi, Sekido Yoshitaka, Mitsudomi Tetsuya

Abstract excerpt

INTRODUCTION: Mesenchymal status is related to "inherent resistance" to gefitinib or erlotinib in non-small cell lung cancer without epidermal growth factor receptor(EGFR) mutations. In addition, a recent report showed that the epithelial to mesenchymal transition (EMT) plays a role in acquired resistance to gefitinib in A549 cells, which harbor a KRAS mutation. However, recent clinical studies revealed that...

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Identifiers

PMID: 21597390
DOI: 10.1097/JTO.0b013e318216ee52

Genes

EGFR
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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