Article
Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.
International journal of oncology - 1 May 2016
Kurimoto Ryota, Iwasawa Shunichiro, Ebata Takahiro, Ishiwata Tsukasa, Sekine Ikuo, Tada Yuji, Tatsumi Koichiro, Koide Shuhei, Iwama Atsushi, Takiguchi Yuichi
Abstract excerpt
Epithelial-to-mesenchymal transition (EMT) is a malignant cancer phenotype characterized by augmented invasion and metastasis, chemoresistance, and escape from host-immunity. This study sought to identify efficient methods for inducing EMT reversion, to evaluate alterations in chemosensitivity and immune-protectiveness, and to elucidate the underlying mechanisms. In this study, the human lung adenocarcinoma cell...
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