Article
Epithelial phenotype as a predictive marker for response to EGFR-TKIs in non-small cell lung cancer patients with wild-type EGFR.
International journal of cancer - 15 Dec 2014
Ren Shengxiang, Su Chunxia, Wang Zhaoye, Li Jiayu, Fan Lihong, Li Bing, Li Xuefei, Zhao Cao, Wu Chunyan, Hou Likun, He Yayi, Gao Guanghui, Chen Xiaoxia, Ren Jiawei, Li Aiwu, Xu Guotong, Zhou Xiao, Zhou Caicun, Schmid-Bindert Gerald
Abstract excerpt
Epithelial-to-mesenchymal transition (EMT) has profound impacts on cancer progression and also on drug resistance, including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Nowadays, there is still no predictive biomarker identified for the use of EGFR-TKIs in non-small cell lung cancer (NSCLC) patients with wild-type EGFR. To clarify the role of EMT phenotype as a predictive marker for...
Topics
- Aged
- Antigens, CD
- Biomarkers
- Cadherins
- Carcinoma, Non-Small-Cell Lung
- Disease Progression
- Drug Resistance, Neoplasm
- Epithelial-Mesenchymal Transition
- Epithelium