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Article

High frequencies of asymptomatic Epstein-Barr virus viremia in affected and unaffected individuals with CTLA4 mutations.

Clinical immunology (Orlando, Fla.) - 1 Oct 2018

Hoshino Akihiro, Tanita Kay, Kanda Kenji, Imadome Ken-Ichi, Shikama Yoshiaki, Yasumi Takahiro, Imai Kohsuke, Takagi Masatoshi, Morio Tomohiro, Kanegane Hirokazu

Abstract excerpt

Patients with CTLA4 mutations present with autoimmune diseases, lymphoproliferation, and hypogammaglobulinemia, and a subset of patients developed Epstein-Barr virus (EBV)-associated malignancies, suggesting an impaired immune function against EBV. Here we investigated EBV infection in individuals with CTLA4 mutations. We measured EBV viral DNA in healthy individuals, individuals with autoimmune diseases, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30048690
DOI: 10.1016/j.clim.2018.07.012

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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