Multifocal HPV16-positive squamous cell carcinomas in CTLA-4 haploinsufficiency: expanding the spectrum of virus-associated malignancies.

doi:10.1007/s12026-026-09830-x

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Multifocal HPV16-positive squamous cell carcinomas in CTLA-4 haploinsufficiency: expanding the spectrum of virus-associated malignancies.

Immunologic research - 25 Aug 2026

Moen Christian Arvei, Mohn Kristin Greve-Isdahl, Marks Alexander, Falkenthal Thea E Hetland, Juliebø-Jones Patrick, Aarstad Hans Jørgen, Moe Svein Erik, Beisland Christian, Costea Daniela Elena, Ognedal Elisabet, Bratland Eirik, Vetti Hildegunn Høberg, Berget Ellen

Abstract excerpt

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) haploinsufficiency is an inborn error of immunity characterized by immune dysregulation, autoimmunity, lymphoproliferation, and an increased risk of malignancy. While susceptibility to oncogenic viral infections has been proposed, the relationship between CTLA-4 haploinsufficiency and human papillomavirus (HPV)-driven carcinogenesis remains poorly...

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Share to Carcinoma, Squamous Cell
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Share to Genetic Predisposition to Disease

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Identifiers

PMID: 42640348
DOI: 10.1007/s12026-026-09830-x
PMCID: PMC13506675

Genes

CTLA4

Variants

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