Article
Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotype.
Arthritis and rheumatism - 1 Apr 2005
Parks Christine G, Cooper Glinda S, Hudson Lori L, Dooley Mary Anne, Treadwell Edward L, St Clair E W, Gilkeson Gary S, Pandey Janardan P
Abstract excerpt
OBJECTIVE: Epstein-Barr virus (EBV) is hypothesized to play a role in the development of systemic lupus erythematosus (SLE). Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is important in regulating T cell-mediated immunity, encompassing the first line of response to viral infections, and genetic variation in CTLA-4 has been associated with SLE. This study examined the seroprevalence of EBV in a...
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