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Linking genetics to epigenetics: The role of folate and folate-related pathways in neurodevelopmental disorders.

Clinical genetics - 1 Feb 2019

Lintas C

Abstract excerpt

There is growing evidence that epigenetic dysregulation plays a role in neurodevelopmental disorders. In humans, folate is one of the main donors of the methyl group required for the synthesis of S-adenosylmethionine, which in turn is needed for DNA and histone methylation as key neurodevelopment processes. Folate deficiency during pregnancy has been correlated with neural tube defects and with a higher incidence...

Topics

Animals
Biomarkers
DNA Methylation
Diet
Epigenesis, Genetic
Folic Acid
Gene Expression Regulation
Genetic Predisposition to Disease
Genetic Variation
Humans
Metabolic Networks and Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurodevelopmental Disorders

Neurogenesis

Source

Identifiers

PMID: 30047142
DOI: 10.1111/cge.13421

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