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Article

Differential regulation of the Wnt/β-catenin pathway by hepatitis C virus recombinants expressing core from various genotypes.

Scientific reports - 25 Jul 2018

Aicher Stephanie, Kakkanas Athanasios, Cohen Lisette, Blumen Brigitte, Oprisan Gabriela, Njouom Richard, Meurs Eliane F, Mavromara Penelope, Martin Annette

Abstract excerpt

Clinical studies have suggested association of some hepatitis C virus (HCV) subtypes or isolates with progression toward hepatocellular carcinoma (HCC). HCV core protein has been reported to interfere with host Wnt/β-catenin pathway, a cell fate-determining pathway, which plays a major role in HCC. Here, we investigated the impact of HCV core genetic variability in the dysregulation of Wnt/β-catenin pathway. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30046100
DOI: 10.1038/s41598-018-29078-2
PMCID: PMC6060129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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