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Article

Replicating parvoviruses that target colon cancer cells.

Journal of virology - 1 Jun 2003

Malerba M, Daeffler L, Rommelaere J, Iggo R D

Abstract excerpt

The wnt signaling pathway is constitutively activated in colon tumors by mutations in the adenomatous polyposis coli and beta-catenin genes. We have modified the minute virus of mice (MVM) P4 promoter to make it responsive to wnt signaling by inserting binding sites for the heterodimeric beta-catenin/Tcf transcription factor. In luciferase assays we can see up to 20-fold selectivity of Tcf mutant P4 promoters for...

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Identifiers

PMID: 12767988
DOI: 10.1128/jvi.77.12.6683-6691.2003
PMCID: PMC156172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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