Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients.

doi:10.1111/jcmm.13717

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Article

Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients.

Journal of cellular and molecular medicine - 1 Oct 2018

Costa Nara Aline, Gut Ana Lúcia, Azevedo Paula Schmidt, Polegato Bertha Furlan, Magalhães Eloá Siqueira, Ishikawa Larissa Lumi Watanabe, Bruder Rita de Cassia Siqueira, Silva Evelyn Aparecida da, Gonçalves Renan Braga, Tanni Suzana Erico, Rogero Marcelo Macedo, Norde Marina Maintinguer, Cunha Natália Baraldi, Zornoff Leonardo Antonio Mamede, de Paiva Sergio Alberto Rupp, Minicucci Marcos Ferreira

Abstract excerpt

The objective of our study was to evaluate the association between peptidylarginine deiminase 4 (PAD4) concentration and its polymorphisms with mortality in patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit (ICU) admission. However, 48 patients were excluded. Thus, 127 patients were enrolled in the study. At the time of the patients'...

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PMID: 30044533
DOI: 10.1111/jcmm.13717
PMCID: PMC6156447

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PADI4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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