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Article

A Three-Factor Structure of Cognitive Functioning Among Unimpaired Carriers and Non-Carriers of Autosomal-Dominant Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Guzmán-Vélez Edmarie, Jaimes Sehily, Aguirre-Acevedo Daniel C, Norton Daniel J, Papp Kathryn V, Amariglio Rebecca, Rentz Dorene, Baena Ana, Henao Eliana, Tirado Victoria, Muñoz Claudia, Giraldo Margarita, Sperling Reisa A, Lopera Francisco, Quiroz Yakeel T

Abstract excerpt

BACKGROUND: There is a need to find cognitive markers that can help identify individuals at risk for Alzheimer's disease (AD), and that can be used to reliably measure cognitive decline. OBJECTIVE: We tested whether a theoretically driven three-factor structure would characterize cognitive functioning in individuals who are genetically-determined to develop AD due to a mutation in Presenilin-1 (PSEN1) gene. We...

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Source

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Identifiers

PMID: 30040714
DOI: 10.3233/JAD-180078
PMCID: PMC6942670

Genes

PSEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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