The Alzheimer's prevention initiative composite cognitive test score: sample size estimates for the evaluation of preclinical Alzheimer's disease treatments in presenilin 1 E280A mutation carriers.

doi:10.4088/JCP.13m08927

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Article

The Alzheimer's prevention initiative composite cognitive test score: sample size estimates for the evaluation of preclinical Alzheimer's disease treatments in presenilin 1 E280A mutation carriers.

The Journal of clinical psychiatry - 1 Jun 2014

Ayutyanont Napatkamon, Langbaum Jessica B S, Hendrix Suzanne B, Chen Kewei, Fleisher Adam S, Friesenhahn Michel, Ward Michael, Aguirre Camilo, Acosta-Baena Natalia, Madrigal Lucìa, Muñoz Claudia, Tirado Victoria, Moreno Sonia, Tariot Pierre N, Lopera Francisco, Reiman Eric M

Abstract excerpt

OBJECTIVE: To identify a cognitive composite that is sensitive to tracking preclinical Alzheimer's disease decline to be used as a primary end point in treatment trials. METHOD: We capitalized on longitudinal data collected from 1995 to 2010 from cognitively unimpaired presenilin 1 (PSEN1) E280A mutation carriers from the world's largest known early-onset autosomal dominant Alzheimer's disease kindred to identify...

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Identifiers

PMID: 24816373
DOI: 10.4088/JCP.13m08927
PMCID: PMC4331113

Genes

PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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