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Article

Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling

20 Jul 2018

Abstract excerpt

Timely controlled oxygen (O 2 ) delivery is crucial for the developing liver. However, the influence of O 2 on intercellular communication during hepatogenesis is unclear. Using a human induced pluripotent stem cell-derived liver bud (hiPSC-LB) model, we found hypoxia induced with an O 2 -permeable plate promoted hepatic differentiation accompanied by TGFB1 and TGFB3 suppression. Conversely, extensive hypoxia...

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PMID: 30033085
DOI: 10.1016/j.stemcr.2018.06.015

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