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Placenta-derived factors contribute to human iPSC-liver organoid growth

13 Mar 2025

Abstract excerpt

Organoids derived from human induced pluripotent stem cells (hiPSC) are potentially applicable for regenerative medicine. However, the applications have been hampered by limited organoid size and function as a consequence of a lack of progenitor expansion. Here, we report the recapitulation of progenitor expansion in hiPSC-liver organoids based on the analysis of mouse development. Visualization of blood...

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PMID: 40082402
DOI: 10.1038/s41467-025-57551-w

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