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Article

HSP70iQ435A-Encoding DNA Repigments Vitiligo Lesions in Sinclair Swine.

The Journal of investigative dermatology - 1 Dec 2018

Henning Steven W, Fernandez Manuel F, Mahon James P, Duff Richard, Azarafrooz Farshid, Guevara-Patiño José A, Rademaker Alfred W, Salzman Andrew L, Le Poole I Caroline

Abstract excerpt

Human HSP70iQ435A carries a single amino-acid modification within the dendritic cell activating region and tolerizes dendritic cells in vitro. The underlying DNA was used to prevent and treat disease in vitiligo mouse models through reduced dendritic cell activation and diminished skin T-cell infiltration, suggesting the same may be useful for patients. Physiologic differences between mouse and human skin then...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30031029
DOI: 10.1016/j.jid.2018.06.186
PMCID: PMC9732057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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