Article
Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2007
Wolchok Jedd D, Yuan Jianda, Houghton Alan N, Gallardo Humilidad F, Rasalan Teresa S, Wang Jian, Zhang Yan, Ranganathan Rajaram, Chapman Paul B, Krown Susan E, Livingston Philip O, Heywood Melanie, Riviere Isabelle, Panageas Katherine S, Terzulli Stephanie L, Perales Miguel A
Abstract excerpt
Immunity to self antigens on cancer is constrained by tolerance/ignorance. DNA vaccines encoding xenogeneic differentiation antigens, such as tyrosinase (TYR), mediate tumor protection and regression in implantable mouse models, and dogs with spontaneous melanoma. We conducted a trial of mouse and human TYR DNA vaccines in stage III/IV melanoma patients. Eighteen human leukocyte antigen (HLA)-A*0201(+) melanoma...
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