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Article

Electrostatic Tuning of the Ligand Binding Mechanism by Glu27 in Nitrophorin 7.

Scientific reports - 18 Jul 2018

Abbruzzetti Stefania, Allegri Alessandro, Bidon-Chanal Axel, Ogata Hideaki, Soavi Giancarlo, Cerullo Giulio, Bruno Stefano, Montali Chiara, Luque F Javier, Viappiani Cristiano

Abstract excerpt

Nitrophorins (NP) 1-7 are NO-carrying heme proteins found in the saliva of the blood-sucking insect Rhodnius prolixus. The isoform NP7 displays peculiar properties, such as an abnormally high isoelectric point, the ability to bind negatively charged membranes, and a strong pH sensitivity of NO affinity. A unique trait of NP7 is the presence of Glu in position 27, which is occupied by Val in other NPs. Glu27...

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Identifiers

PMID: 30022039
DOI: 10.1038/s41598-018-29182-3
PMCID: PMC6052033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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