Article
Kinetics and computational studies of ligand migration in nitrophorin 7 and its Δ1-3 mutant.
Biochimica et biophysica acta - 1 Sept 2013
Oliveira Ana, Allegri Alessandro, Bidon-Chanal Axel, Knipp Markus, Roitberg Adrian E, Abbruzzetti Stefania, Viappiani Cristiano, Luque F Javier
Abstract excerpt
Nitrophorins (NPs) are nitric oxide (NO)-carrying heme proteins found in the saliva of the blood-sucking insect Rhodnius prolixus. Though NP7 exhibits a large sequence resemblance with other NPs, two major differential features are the ability to interact with negatively charged cell surfaces and the presence of a specific N-terminus composed of three extra residues (Leu1-Pro2-Gly3). The aim of this study is to...
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