Article
Determination of ligand pathways in globins: apolar tunnels versus polar gates.
The Journal of biological chemistry - 28 Sept 2012
Salter Mallory D, Blouin George C, Soman Jayashree, Singleton Eileen W, Dewilde Sylvia, Moens Luc, Pesce Alessandra, Nardini Marco, Bolognesi Martino, Olson John S
Abstract excerpt
Although molecular dynamics simulations suggest multiple interior pathways for O(2) entry into and exit from globins, most experiments indicate well defined single pathways. In 2001, we highlighted the effects of large-to-small amino acid replacements on rates for ligand entry and exit onto the t...
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