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Article

SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement.

Journal of virology - 1 Oct 2018

Alsahafi Nirmin, Anand Sai Priya, Castillo-Menendez Luis, Verly Myriam Maude, Medjahed Halima, Prévost Jérémie, Herschhorn Alon, Richard Jonathan, Schön Arne, Melillo Bruno, Freire Ernesto, Smith Amos B, Sodroski Joseph, Finzi Andrés

Abstract excerpt

The entry of human immunodeficiency virus into host cells is mediated by the envelope glycoprotein (Env) trimeric spike, which consists of three exterior gp120 subunits and three transmembrane gp41 subunits. The trimeric Env undergoes extensive conformational rearrangement upon interaction with the CD4 receptor, transitioning from the unliganded, "closed" State 1 to more-open downstream State 2 and State 3...

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Share to CD4 Antigens
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to HIV Envelope Protein gp120

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Share to HIV Infections

Share to Mutagenesis, Site-Directed

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Source

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Identifiers

PMID: 30021898
DOI: 10.1128/JVI.01080-18
PMCID: PMC6146791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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