Inter- and intraspecies metabolite exchange promotes virulence of antibiotic-resistant Staphylococcus aureus.

Abstract excerpt

Adaptations that enable antimicrobial resistance often pose a fitness cost to the microorganism. Resistant pathogens must therefore overcome such fitness decreases to persist within their hosts. Here we demonstrate that the reduced fitness associated with one resistance-conferring mutation can be offset by community interactions with microorganisms harboring alternative mutations or via interactions with the...

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