Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelope fitness factors.

doi:10.1371/journal.pone.0029023

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Article

Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelope fitness factors.

PloS one - 1 Jan 2011

Rigottier-Gois Lionel, Alberti Adriana, Houel Armel, Taly Jean-François, Palcy Philippe, Manson Janet, Pinto Daniela, Matos Renata C, Carrilero Laura, Montero Natalia, Tariq Muhammad, Karsens Harma, Repp Christian, Kropec Andrea, Budin-Verneuil Aurélie, Benachour Abdellah, Sauvageot Nicolas, Bizzini Alain, Gilmore Michael S, Bessières Philippe, Kok Jan, Huebner Johannes, Lopes Fatima, Gonzalez-Zorn Bruno, Hartke Axel, Serror Pascale

Abstract excerpt

Spread of antibiotic resistance among bacteria responsible for nosocomial and community-acquired infections urges for novel therapeutic or prophylactic targets and for innovative pathogen-specific antibacterial compounds. Major challenges are posed by opportunistic pathogens belonging to the low GC% gram-positive bacteria. Among those, Enterococcus faecalis is a leading cause of hospital-acquired infections...

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PMID: 22194979
DOI: 10.1371/journal.pone.0029023
PMCID: PMC3240637

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