Article
Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis.
PloS one - 1 Jan 2013
Schwede Matthew, Spentzos Dimitrios, Bentink Stefan, Hofmann Oliver, Haibe-Kains Benjamin, Harrington David, Quackenbush John, Culhane Aedín C
Abstract excerpt
Although ovarian cancer is often initially chemotherapy-sensitive, the vast majority of tumors eventually relapse and patients die of increasingly aggressive disease. Cancer stem cells are believed to have properties that allow them to survive therapy and may drive recurrent tumor growth. Cancer stem cells or cancer-initiating cells are a rare cell population and difficult to isolate experimentally. Genes that...
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