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Multiple cis -regulatory elements control prox1a expression in distinct lymphatic vascular beds

1 May 2024

Abstract excerpt

During embryonic development, lymphatic endothelial cell (LEC) precursors are distinguished from blood endothelial cells by the expression of Prospero-related homeobox 1 (Prox1), which is essential for lymphatic vasculature formation in mouse and zebrafish. Prox1 expression initiation precedes LEC sprouting and migration, serving as the marker of specified LECs. Despite its crucial role in lymphatic development,...

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PMID: 38722096
DOI: 10.1242/dev.202525

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