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Article

Divergence of zebrafish and mouse lymphatic cell fate specification pathways.

Development (Cambridge, England) - 1 Mar 2014

van Impel Andreas, Zhao Zhonghua, Hermkens Dorien M A, Roukens M Guy, Fischer Johanna C, Peterson-Maduro Josi, Duckers Henricus, Ober Elke A, Ingham Philip W, Schulte-Merker Stefan

Abstract excerpt

In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. Its restricted expression in a subset of cardinal vein cells leads to a switch towards lymphatic specification and hence represents a prerequisite for the initiation of lymphangiogenesis. Murine Prox1-null embryos lack lymphatic structures, and sustained expression of Prox1 is indispensable for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24523456
DOI: 10.1242/dev.105031
PMCID: PMC3943180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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