Article
Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody.
EMBO reports - 5 Apr 2022
Tvorogov Denis, Thompson-Peach Chloe A L, Foßelteder Johannes, Dottore Mara, Stomski Frank, Onnesha Suraiya A, Lim Kelly, Moretti Paul A B, Pitson Stuart M, Ross David M, Reinisch Andreas, Thomas Daniel, Lopez Angel F
Abstract excerpt
Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulum retention signal, creating a neoepitope potentially targetable by immunotherapeutic approaches. We developed a specific rat monoclonal IgG2α antibody, 4D7, directed against the common sequence encoded by both insertion and deletion mutations. 4D7 selectively bound to cells co-expressing mutant CALR...
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