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Article

Mutation tryptophan to leucine at position 222 of haemagglutinin could facilitate H3N2 influenza A virus infection in dogs.

The Journal of general virology - 1 Dec 2013

Yang Guohua, Li Shoujun, Blackmon Sherry, Ye Jianqiang, Bradley Konrad C, Cooley Jim, Smith Dave, Hanson Larry, Cardona Carol, Steinhauer David A, Webby Richard, Liao Ming, Wan Xiu-Feng

Abstract excerpt

An avian-like H3N2 influenza A virus (IAV) has recently caused sporadic canine influenza outbreaks in China and Korea, but the molecular mechanisms involved in the interspecies transmission of H3N2 IAV from avian to canine species are not well understood. Sequence analysis showed that residue 222 in haemagglutinin (HA) is predominantly tryptophan (W) in the closely related avian H3N2 IAV, but was leucine (L) in...

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Identifiers

PMID: 23994833
DOI: 10.1099/vir.0.054692-0
PMCID: PMC4093785

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