Article
The association of genomic lesions and PD-1/PD-L1 expression in resected triple-negative breast cancers.
Breast cancer research : BCR - 11 Jul 2018
Barrett Michael T, Lenkiewicz Elizabeth, Malasi Smriti, Basu Anamika, Yearley Jennifer Holmes, Annamalai Lakshmanan, McCullough Ann E, Kosiorek Heidi E, Narang Pooja, Wilson Sayres Melissa A, Chen Meixuan, Anderson Karen S, Pockaj Barbara A
Abstract excerpt
BACKGROUND: Elevated PD-L1 expression on tumor cells, a context associated with an adaptive immune response, has been linked to the total burden of copy number variants (CNVs) in aneuploid tumors, to microsatellite instability (MSI), and to specific genomic driver lesions, including loss of PTEN, MYC amplification, and activating mutations in driver oncogenes such as KRAS and PIK3CA. Triple-negative breast...
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