Article
Identifying diagnosis-specific genotype-phenotype associations via joint multitask sparse canonical correlation analysis and classification.
Bioinformatics (Oxford, England) - 1 Jul 2020
Du Lei, Liu Fang, Liu Kefei, Yao Xiaohui, Risacher Shannon L, Han Junwei, Guo Lei, Saykin Andrew J, Shen Li
Abstract excerpt
MOTIVATION: Brain imaging genetics studies the complex associations between genotypic data such as single nucleotide polymorphisms (SNPs) and imaging quantitative traits (QTs). The neurodegenerative disorders usually exhibit the diversity and heterogeneity, originating from which different diagnostic groups might carry distinct imaging QTs, SNPs and their interactions. Sparse canonical correlation analysis (SCCA)...
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