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Article

Coexisting driver mutations in MPN: clinical and molecular characteristics of a series of 11 patients.

Hematology (Amsterdam, Netherlands) - 1 Dec 2018

De Roeck L, Michaux L, Debackere K, Lierman E, Vandenberghe P, Devos T

Abstract excerpt

OBJECTIVES: CML, PV, ET and PMF are so called classical MPN with distinct clinical phenotypes. The discovery of the BCR-ABL1 translocation and mutations in driver genes JAK2, MPL and CALR has provided novel insights in their pathogenesis. While these mutations are thought to be mutually exclusive, rare cases of MPN with coexisting driver mutations have been reported. However, little is known about the clinical,...

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Source

Identifiers

PMID: 29993347
DOI: 10.1080/10245332.2018.1498182

Genes

JAK2
ABL1
BCR
CALR
MPL

Variants

Provenance

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