Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered monocyte phenotypes but not impaired peripheral T cell immunity may explain susceptibility of the elderly to develop tuberculosis.

Experimental gerontology - 1 Oct 2018

Ault Russell, Dwivedi Varun, Koivisto Elisha, Nagy Jenna, Miller Karin, Nagendran Kokila, Chalana Indu, Pan Xueliang, Wang Shu-Hua, Turner Joanne

Abstract excerpt

Tuberculosis (TB) is the leading killer due to a single infectious disease worldwide. With the aging of the global population, the case rate and deaths due to TB are highest in the elderly population. While general immunosenescence associated with old age is thought to contribute to the susceptibility of the elderly to develop active TB disease, very few studies of immune function in elderly individuals with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Cytokines

Share to Monocytes

Share to Mycobacterium tuberculosis

Share to T-Lymphocytes

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 29991459
DOI: 10.1016/j.exger.2018.06.029
PMCID: PMC6119637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered monocyte phenotypes but not impaired peripheral T cell immunity may explain susceptibility of the elderly to develop tuberculosis.PMID 29991459Read ↗

Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosisSemantic proximity Read ↗

Immunopathology in human pulmonary tuberculosis: Inflammatory changes in the plasma milieu and impaired host immune cell functionsSemantic proximity Read ↗

Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cellsSemantic proximity Read ↗

Old Mice Express a Transient Early Resistance to Pulmonary Tuberculosis That Is Mediated by CD8 T CellsSemantic proximity Read ↗

Age Impacts the Local Immune Response to Tuberculin Skin Challenge in Mycobacterium Bovis BCG-vaccinated BaboonsSemantic proximity Read ↗

Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life.Semantic proximity Read ↗

BCG Vaccination Induces Trained Innate Immunity in Adults Over 50 Years of Age: A Randomized Trial in Guinea-BissauSemantic proximity Read ↗

T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness".Semantic proximity Read ↗

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment.Semantic proximity Read ↗

Advanced Age Alters Monocyte and Macrophage Responses.Semantic proximity Read ↗

Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection.Semantic proximity Read ↗

Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.