Article
The next generation of complex lung genetic studies.
American journal of respiratory and critical care medicine - 1 Dec 2012
Yang Ivana V, Schwartz David A
Abstract excerpt
Common genetic risk variants identified by genome-wide association studies have explained a small portion of disease heritability in complex diseases. It is becoming apparent that each gene/locus is heterogeneous and that multiple rare independent risk alleles across the population contribute to disease risk. Next-generation sequencing technologies have reached the maturity and low cost necessary to perform whole...
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