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Article

Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia

6 Jul 2018

Abstract excerpt

leukemic stem cell (LSC) counterparts. We observed significantly accelerated telomere shortening in LSC compared with nonleukemic HSC. Interestingly, the degree of LSC telomere shortening was found to correlate significantly with the leukemic clone size. To validate the diagnostic value of nonleukemic cells as internal controls and to rule out effects of tyrosine kinase inhibitor (TKI) treatment on these...

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PMID: 29980572
DOI: 10.1182/bloodadvances.2018017772

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