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Article

Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer.

International journal of cancer - 15 Nov 2018

Xu Yinghui, Liu Hongliang, Liu Shun, Wang Yanru, Xie Jichun, Stinchcombe Thomas E, Su Li, Zhang Ruyang, Christiani David C, Li Wei, Wei Qingyi

Abstract excerpt

The toll-like receptor (TLR) signaling pathway plays an important role in the innate immune responses and antigen-specific acquired immunity. Aberrant activation of the TLR pathway has a significant impact on carcinogenesis or tumor progression. Therefore, we hypothesize that genetic variants in the TLR signaling pathway genes are associated with overall survival (OS) of patients with non-small cell lung cancer...

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Identifiers

PMID: 29978465
DOI: 10.1002/ijc.31660
PMCID: PMC6205899

Genes

IRAK2

Provenance

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