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Reduced HIV-1 latent reservoir outgrowth and distinct immune correlates among women in Rakai, Uganda

16 Jun 2020

Abstract excerpt

HIV-1 infection remains incurable owing to the persistence of a viral reservoir that harbors integrated provirus within host cellular DNA. Increasing evidence links sex-based differences in HIV-1 immune responses and pathogenesis; however, little is known about differences in HIV-1 infection persistence. Here, we quantified persistent HIV-1 infection in 90 adults on suppressive antiretroviral therapy in Rakai,...

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PMID: 32544096
DOI: 10.1172/jci.insight.139287

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