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Article

Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα ‐dependent mechanism

3 Dec 2021

Abstract excerpt

Granulosa cell tumor (GCT) is a form of ovarian tumor characterized by its tendency to recur years after surgical ablation. Little is known about the mechanisms involved in GCT development and progression. GCTs can produce estradiol (E2), but whether this hormone could play a role in this cancer through its nuclear receptors, i.e. ERα and ERβ, remains unknown. Here, we addressed this issue by cell-based and...

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Share to Estrogen and related hormone effects
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PMID: 34860414
DOI: 10.1002/path.5843

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