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Article

Associations between efavirenz concentrations, pharmacogenetics and neurocognitive performance in people living with HIV in Nigeria.

AIDS (London, England) - 1 Oct 2021

Nwogu Jacinta N, Gandhi Monica, Owen Andrew, Khoo Saye H, Taiwo Babafemi, Olagunju Adeniyi, Berzins Baiba, Okochi Hideaki, Tallerico Regina, Robertson Kevin, Babalola Chinedum P

Abstract excerpt

OBJECTIVE: Efavirenz (EFV) use is associated with neuropsychiatric side effects, which may include poor neurocognitive performance. We evaluated single nucleotide polymorphisms in genes that contribute to EFV pharmacokinetics and examined them in association with EFV concentrations in plasma and hair, as well as neurocognitive performance. DESIGN: Cross-sectional study in which adults with HIV receiving 600-mg...

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Identifiers

PMID: 34115651
DOI: 10.1097/QAD.0000000000002984
PMCID: PMC8462442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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