Article
CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population.
Cancer letters - 28 Jul 2005
Zhenhua Li, Tsuchiya Norihiko, Narita Shintaro, Inoue Takamitsu, Horikawa Yohei, Kakinuma Hideaki, Kato Tetsuro, Ogawa Osamu, Habuchi Tomonori
Abstract excerpt
The CYP3A5 gene (CYP3A5) encodes the cytochrome P450 3A5, which catalyzes the 6beta-hydroxylation of testosterone. We explored association between the CYP3A5 A6986G polymorphism and a risk of prostate cancer in 260 prostate cancer patients, 199 BPH patients and 212 male controls. The CYP3A5 gene polymorphism did not influence significantly a risk of developing of prostate cancer in general. However, compared with...
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