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Article

The interaction of CYP3A5 polymorphisms along the androgen metabolism pathway in prostate cancer.

International journal of cancer - 1 Jun 2008

Vaarala Markku H, Mattila Henna, Ohtonen Pasi, Tammela Teuvo L J, Paavonen Timo K, Schleutker Johanna

Abstract excerpt

Prostate cancer is a leading solid tumor among men in the Western world. Androgens play an important role in the carcinogenesis and treatment of prostate cancer. CYP3A5 is a cytochrome P450 superfamily member which also has activity in testosterone metabolism. In this study, we looked for two-gene interactions associated with clinical characteristics of prostate cancer in the Finnish population. We used...

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Identifiers

PMID: 18306354
DOI: 10.1002/ijc.23425

Genes

KLK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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