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Article

Vitamin D receptor: ligand recognition and allosteric network.

Journal of medicinal chemistry - 23 Feb 2006

Yamamoto Keiko, Abe Daijiro, Yoshimoto Nobuko, Choi Mihwa, Yamagishi Kenji, Tokiwa Hiroaki, Shimizu Masato, Makishima Makoto, Yamada Sachiko

Abstract excerpt

To investigate the allosteric effects of ligands in the function of nuclear receptors, we performed exhaustive alanine scanning mutational analysis (ASMA) of the residues lining the ligand-binding pocket (LBP) of the human vitamin D receptor. The effects of ligands were examined in this system (termed two-dimensional (2D) ASMA) using 10 structurally and biologically characteristic ligands that included agonists,...

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Identifiers

PMID: 16480267
DOI: 10.1021/jm050795q

Genes

LBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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