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Article

Metabolic Pulse-Chase RNA Labeling for pri-miRNA Processing Dynamics.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Louloupi Annita, Ørom Ulf Andersson Vang

Abstract excerpt

miRNA biogenesis is a multistep process starting with the cleavage of the primary miRNA transcript in the nucleus by the microprocessor complex. The pri-miRNA processing kinetics has a high impact on the final regulative role of the mature miRNAs on the expression of their target transcripts. Thus studying the in vivo kinetics of the miRNA biogenesis could give more insights into the contribution of each...

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PMID: 29959671
DOI: 10.1007/978-1-4939-8624-8_3

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