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Article

Spectrum of antibacterial activity and mode of action of a novel tris-stilbene bacteriostatic compound.

Scientific reports - 2 May 2018

Man Nikki Y T, Knight Daniel R, Stewart Scott G, McKinley Allan J, Riley Thomas V, Hammer Katherine A

Abstract excerpt

The spectrum of activity and mode of action of a novel antibacterial agent, 135C, was investigated using a range of microbiological and genomic approaches. Compound 135C was active against Gram-positive bacteria with MICs for Staphylococcus aureus ranging from 0.12-0.5 μg/ml. It was largely inactive against Gram-negative bacteria. The compound showed bacteriostatic activity in time-kill studies and did not elicit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29720673
DOI: 10.1038/s41598-018-25080-w
PMCID: PMC5932035

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