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Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy

27 Jun 2018

Abstract excerpt

Cellular therapies based on mesenchymal stromal/stem cells (MSC) are promising strategies in regenerative medicine and oncology. Despite encouraging results, there is still some level of concerns on inoculating MSC in cancer patients. To face this issue, one possibility resides in engineering MSC by incorporating a suicide gene in order to control their fate once infused. Strategies based on Herpes Simplex Virus...

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PMID: 29955091
DOI: 10.1038/s41417-018-0034-1

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