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Article

Generation of Genetically Engineered Precursor T-Cells From Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2016

Hübner Juwita, Hoseini Shahabuddin S, Suerth Julia D, Hoffmann Dirk, Maluski Marcel, Herbst Jessica, Maul Holger, Ghosh Arnab, Eiz-Vesper Britta, Yuan Qinggong, Ott Michael, Heuser Michael, Schambach Axel, Sauer Martin G

Abstract excerpt

Retroviral engineering of hematopoietic stem cell-derived precursor T-cells (preTs) opens the possibility of targeted T-cell transfer across human leukocyte antigen (HLA)-barriers. Alpharetroviral vectors exhibit a more neutral integration pattern thereby reducing the risk of insertional mutagenesis. Cord blood-derived CD34+ cells were transduced and differentiated into preTs in vitro. Two promoters,...

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Share to Antigens, CD34
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Blood

Share to Gene Transfer Techniques

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Share to Hematopoietic Stem Cells

Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 27138041
DOI: 10.1038/mt.2016.89
PMCID: PMC5088766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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