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Article

Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival

3 Jan 2014

Abstract excerpt

The hTERT-immortalization of human bone marrow-derived Mesenchymal Stromal Cells (hMSCs) was proposed to address availability/standardization issues for experimental or clinical studies, but raised concerns due to possible uncontrolled growth or malignant cell transformation. Here we report a method to generate a hMSCs line with controlled survival, through the implementation of a pre-established suicide system...

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PMID: 24561906
DOI: 10.1016/j.scr.2013.12.006

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