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Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors

28 Jun 2018

Abstract excerpt

Elicitation of broadly neutralizing antibodies (bnAbs) is a leading strategy in rational vaccine design against antigenically diverse pathogens. Here, we studied a panel of monoclonal antibodies (mAbs) from mice immunized with the hepatitis C virus (HCV) envelope glycoproteins E1E2. Six of the mAbs recognize the conserved E2 antigenic site 412-423 (AS412) and cross-neutralize diverse HCV genotypes. Immunogenetic...

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Share to Glycosylation and Glycoproteins Research
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PMID: 29954862
DOI: 10.1073/pnas.1802378115

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