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Article

Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals.

PLoS biology - 1 Jun 2018

Sharma Virag, Lehmann Thomas, Stuckas Heiko, Funke Liane, Hiller Michael

Abstract excerpt

Descent of testes from a position near the kidneys into the lower abdomen or into the scrotum is an important developmental process that occurs in all placental mammals, with the exception of five afrotherian lineages. Since soft-tissue structures like testes are not preserved in the fossil record and since key parts of the placental mammal phylogeny remain controversial, it has been debated whether testicular...

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Source

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Identifiers

PMID: 29953435
DOI: 10.1371/journal.pbio.2005293
PMCID: PMC6023123

Genes

RXFP2
INSL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals.PMID 29953435Read ↗

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